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Interleukin-17 Is a Key Cytokine in First-Line Defence of the Skin (Paperback)

Interleukin-17 Is a Key Cytokine in First-Line Defence of the Skin (Paperback)

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Communication between cells as a prerequisite for life of multicellular organisms is achieved mostly by solvent mediators like hormons . neurotransmitters . cytokines and chemokines. Increasing evidence suggests that a class of cytokines exists that signals from immune cells specifically towards epithelial cells. The most prominent member of these "tissue-signaling cytokines" is Interleukin-17 (IL-17). This book illustrates IL-17 is essential to protect the human organism at its skin surface against invading microorganisms. Cellular sources of IL-17 and trigger factors of IL-17 secretion in the skin are defined. Finally . this book identifies two human diseases associated with chronic infections of the skin that are at least partially caused by a disturbed IL-17 pathway - the orphan syndrome "chronic mucocutaneous candidiasis" and the very common inflammatory skin disease "atopic dermatitis/ eczema".

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